A key goal of our drug discovery research is tackling antimicrobial resistance through the identification of bioactive compounds from plants that have the potential to become therapeutic agents in the treatment of tuberculosis
Antibiotic-resistant Mycobacterium tuberculosis strains are jeopardizing efforts in eradicating the global Tuberculosis crisis. Mycobacterium tuberculosis is inherently resistant to many antibiotics limiting the number of compounds accessible for therapy. This inherent resistance is caused by several mechanisms. A key goal of our drug discovery research is tackling antimicrobial resistance through the identification of bioactive compounds from plants that have the potential to become therapeutic agents in the treatment of tuberculosis. Our team leverages core expertise in assay development, high-throughput screening, hit-to-lead medicinal chemistry and in vivo pharmacology to expedite the drug discovery process. Our drug discovery…… Read more
Jones Ofori-Amoah, Cynthia A. Danquah, Kwesi B. Mensah, Emmanuel A. Asiamah, George Owusu, Jones Lamptey, Michael F. Baidoo. 2024. The Hydro-ethanolic Extract of Scoparia dulcis Linn inhibits Allergic Airway Inflammatory Responses in Murine Asthma Models., Phytomedicine Plus, 2024, 100607, ISSN 2667-0313. Read more | |
Phanankosi Moyo, Michael Ofori, Olusola S. Bodede, Madelien Wooding, Ndivhuwo K. Khorommbi, Lyndy J. McGaw, Cynthia A. Danquah &Vinesh J. Maharaj. 2024. Investigation of the antimycobacterial activity of African medicinal plants combined with chemometric analysis to identify potential leads. 2024. Scientific Reports 14(1). Read more | |
Vinesh Maharaj, Phanankosi Moyo, Olusola Bodede, Madelien Wooding, Ibukun Famuyide, Fikile Makhubu, and Kevin N. Khorommbi, Michael Ofori, Cynthia A. Danquah, and Lyndy McGaw. 2024. In Vitro Antiquorum Sensing Activity of Extracts and Solid Phase Extraction Generated Fractions of South African Medicinal Plants. Read more | |
Mavis S. Nyarko, Cynthia A. Danquah, Aaron O. Antwi. Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis. November 2023. Scientific African 23(2): e02004. Read more | |
Felix K. Zoiku, Rita Sewornu, Nancy O. Duah-Quashie, Michael Ofori, Sherif Hamidu, Neils B. Quashie and Cynthia A. Danquah. 2024. Antibacterial and Antibiofilm Activities of Selected Herbal Products in Ghana. 2024. Read more |
At IOI, scientists are working to develop solutions to this global health challenge, including developing new antibiotic therapies. 6/6
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The successful development of the antibiotic was the result of collaboration between academia, industry and government.
After the War, the "Golden Age of Antibiotics" began, where the majority of antibiotic classes in use today were discovered. 4/6
When World War II broke out, there was an urgent need for new life-saving medicines.
In 1941 Florey and Chain travelled to America to speak with US government officials and pharmaceutical companies about the potential of penicillin. 3/6
The life-saving antibiotic was first discovered by Alexander Fleming in 1928, and isolated in 1940 by Howard Florey and Ernst Chain at @UniofOxford. 2/6
